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Jul 17, 2023

Pharmaceutical Vial Powder Filling Equipment

Pharmaceutical powders form the basis of numerous antibiotics and other medicines that are essential for comprehensive medical care. While liquid pharmaceuticals are already challenging to fill,

Pharmaceutical powders form the basis of numerous antibiotics and other medicines that are essential for comprehensive medical care. While liquid pharmaceuticals are already challenging to fill, powders add a level of complexity due to their consistency. The finely ground active ingredients generate dust easily. Hence, machine operators must be protected from these sometimes toxic or potent ingredients and vice versa. With more than 250 machines sold globally, Syntegon has been supporting customers in pharmaceutical powder filling for more than 60 years. Our experts will be happy to pass on their expertise to you, too!

Antibiotic powders for injection:

Sterile powders are a common and important dosage form for active molecules that are not stable in an aqueous/liquid environment and cannot be marketed as ready-to-use injectables. Typical molecules in this category include beta-lactam antibiotics such as penicillin, cephalosporins, or acyclovir.

Micro pellets:

Spray-freeze-dried pellets are an innovative drug form. Sterile medicines are freeze-dried to very small but uniform balls. The main drivers of this promising lyophilization process: higher possible concentrated protein formulations, flexibility in mixing various pellets/spheres, as well as logistic advantages.

Other sterile powders:

Apart from antibiotics, there are further powders used for injection. Their formulation consists of drugs only or drug and excipient, both in a crystalline form. This dosage form is less cost-sensitive compared to directly lyophilized primary vials, since they require less energy and less infrastructure for aseptic production.

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